Glycated Hemoglobin is a Significant Predictor of Femoral, but Not of Carotid or Popliteal, Intima-Media Thickness in Adolescents with Type 1 Diabetes: A Case-Series Study
Authors' conclusion
In adolescents with T1D, cardiovascular risk factors deteriorate with worsening blood glucose control. In the early stages of T1D, femoral IMT may serve as a more sensitive surrogate marker for hyperglycemia-induced subclinical atherosclerosis, an effect that may not be mediated by alterations in cardiovascular functions.
Study context
- Population
- Adolescents with T1D (15.9 ± 4.9 years; 42.0% male); B-mode US measurement of carotid, femoral and popliteal intima-media thickness (IMT)
- Participants
- 286 adolescents
- Comparison
- Hemoglobin A1c (HbA1c) >10% vs ≤10%
- Outcome
- Site-dependent relationship between IMT (carotid, femoral, popliteal) and cardiovascular risk factors
Methodological detailslinear mixed-effects model, mediation analysis
- Linear mixed-effects model
- Mediation analysis
Main finding
As reported in the abstract
IMT by arterial site
- HbA1c >10% vs ≤10%: thicker femoral IMT, but not carotid or popliteal IMT
Further findings
Cardiovascular risk factors by HbA1c
- Glycemic parameters, lipids, uric acid, high-sensitivity C-reactive protein and advanced glycation end-products worsened with increasing HbA1c
Cardiovascular functions
- Poorer diabetic control: significant changes in central systolic blood pressure (BP), left ventricular (LV) ejection time, LV dp/dt max, stroke volume and brachial artery compliance
- None of these cardiovascular functions mediated the relationship between higher HbA1c and greater femoral IMT
- Standard mediation analysis
Original publication
Glycated Hemoglobin is a Significant Predictor of Femoral, but Not of Carotid or Popliteal, Intima-Media Thickness in Adolescents with Type 1 Diabetes: A Case-Series Study. Pediatr Diabetes. Published 31 March 2023. doi:10.
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