Gestational diabetes & diabetes in pregnancy
Increased gallbladder emptying and reduced GLP ‐1 response in pregnancy with and without gestational diabetes mellitus
Authors' conclusion
Pregnancy-induced changes in gallbladder motility seem to play no or a limited role in previously reported GDM-associated reduced postprandial GLP-1 responses as gallbladder emptying was greater and postprandial GLP-1 response was lower in pregnancy than postpartum regardless of GDM status.
Study context
- Population
- Pregnant women with and without gestational diabetes mellitus (GDM); median age 31 vs 32 years, body mass index (BMI) 27.2 vs 28.4 kg/m², HbA1c 30 vs 30 mmol/mol
- Participants
- 15 vs 15
- Exposure
- GDM vs normal glucose tolerance (NGT) pregnancy; pregnancy vs postpartum
- GDMn = 15
- NGTn = 15reference
- Outcome
- Postprandial gallbladder emptying (US-assessed) and GLP-1 responses during 240-min mixed meal tests
- Follow-up
- Third trimester and 3-6 months postpartum
Methodological detailsmixed meal tests in third trimester and 3-6 months postpartum
- Mixed meal tests in third trimester and 3-6 months postpartum
Main finding
As reported in the abstract
Postprandial gallbladder emptying and GLP-1 responses, GDM vs NGT · pregnancy and postpartum
- No differences in postprandial gallbladder emptying or GLP-1 responses between GDM and NGT, neither during pregnancy nor postpartum
Observational data: associations, not effects.
Further findings
Median, %
| Outcome | GDM | NGT |
|---|---|---|
| Fasting gallbladder volume increase, pregnancy vs postpartum | 69 (IQR 30–122) | 103 (IQR 59–156) |
| Postprandial gallbladder emptying increase, pregnancy vs postpartum | 77 (IQR 28–236) | 99 (IQR 37–190) |
| Postprandial GLP-1 response reduction, pregnancy vs postpartum | 60 (IQR 3–82) | 81 (IQR 11–90) |
Original publication
Increased gallbladder emptying and reduced GLP ‐1 response in pregnancy with and without gestational diabetes mellitus. Diabetes Obes Metab. Published 14 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →