Increased cardiovascular risk in people with latent autoimmune diabetes in adults (LADA) in comparison to type 1 diabetes and type 2 diabetes: Findings from the DPV registry in Germany and Austria
Authors' conclusion
People with LADA had a higher prevalence of cardiovascular risk factors (dyslipidemia, hypertension) and cardiovascular complications (DKD and peripheral neuropathy), suggesting that people with LADA are at need for improved recognition and care.
Study context
- Population
- People with diabetes diagnosed at age 30–70 years in the DPV registry (Germany and Austria), 1995 to 2022; analysed at diagnosis and follow-up (≥6 months after diagnosis)
- Participants
- 36,959 people
- Exposure
- LADA vs T1D vs T2D
- LADAn = 747
- T1Dn = 940
- T2Dn = 35,272
- Outcome
- Prevalence of dyslipidemia, adjusted for age, sex and diabetes duration
- Follow-up
- follow-up
Methodological detailsregistry-based (DPV), real-world, adjusted for age, sex and diabetes duration
- Registry-based (DPV)
- Real-world
- Adjusted for age, sex and diabetes duration
Main finding
As reported in the abstract
P < 0.01
Observational data: associations, not effects.
Further findings
Prevalence of hypertension, adjusted for age, sex and diabetes duration · follow-up — LADA vs T2D · highest in LADA vs T2D and T1D
P < 0.01
Prevalence of peripheral neuropathy · follow-up — LADA vs T2D · higher in LADA than T2D and T1D
P < 0.05
Treatment coverage for hypertension · follow-up
Treatment coverage for dyslipidemia · follow-up
| Outcome | LADA | T1D | T2D | P value |
|---|---|---|---|---|
| Prevalence of DKD · follow-upLADA vs T1D · higher in LADA | 44.2% | 19.9% | — not stated in the abstract | P < 0.01 |
— not stated in the abstract
Characteristics at diagnosis (age, BMI, waist circumference, C-peptide, HbA1c)
- Values in LADA fell in between T1D and T2D (all p-values < 0.01)
Original publication
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