Incidence of Latent Autoimmune Diabetes in Adults (LADA) and Type 2 Diabetes in Relation to Tobacco Use and Genetic Susceptibility to Type 2 Diabetes and Related Traits: Findings From a Swedish Case-Control Study and the Norwegian HUNT Study
Authors' conclusion
Tobacco use may confer a higher risk of LADA in individuals with genetic susceptibility to T2D and insulin resistance, whereas genetic susceptibility does not seem to influence the increased T2D incidence associated with tobacco use.
Study context
- Population
- Two population-based Scandinavian studies: LADA cases, T2D cases, matched controls; 1,696,503 person-years at risk1,696,503 person-years · LADA cases 839 · T2D cases 5,771 · matched controls 3,068
- Comparison
- Tobacco use and genetic risk scores: interaction on LADA and T2D risk
- Outcome
- Incidence of LADA and T2D by tobacco use and GRS; additive (AP) and multiplicative interaction
Methodological detailsmatched control subjects, Swedish case-control study and Norwegian HUNT study
- Matched control subjects
- Swedish case-control study and Norwegian HUNT study
Pooled result
As reported in the abstract
LADA
Each group vs low IR-GRS without heavy useRelative risk (CI)
High IR-GRS heavy smokers
2.01(1.30–3.10)
High IR-GRS tobacco users
2.59(1.54–4.35)
- Additive interaction, smoking × IR-GRS (AP)
- 0.67 [CI 0.46, 0.89]
- Additive interaction, tobacco × IR-GRS (AP)
- 0.52 [CI 0.21, 0.83]
- Multiplicative interaction, smoking × IR-GRS
- P = 0.003
- Multiplicative interaction, tobacco × IR-GRS
- P = 0.034
Further pooled results
- Excess risk conferred by tobacco use did not differ across GRS categories in T2D
Original publication
Incidence of LADA and Type 2 Diabetes in Relation to Tobacco Use and Genetic Susceptibility to Type 2 Diabetes and Related Traits: Findings From a Swedish Case-Control Study and the Norwegian HUNT Study. Diabetes Care. Published 3 March 2023. doi:10.
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