Cancer Outcomes Among Prediabetes and Type 2 Diabetes Populations With Dietary and Physical Activity–based Lifestyle Interventions
Pooled result · Cancer mortalityResult — go to the resultRelative risk 0.94 95% CI 0.81–1.10Authors' conclusion
Based on the limited data available, dietary and physical activity-based lifestyle interventions had no superiority to usual care on reducing cancer risk in populations with prediabetes and T2D. Lifestyle interventions focused on cancer outcomes should be tested to better explore their effects.
Study context
- Population
- Prediabetes or T2D populations in RCTs with at least 24 months of lifestyle interventions
- Participants
- 12,841 participants6 trials
- Comparison
- Dietary and physical activity-based lifestyle interventions vs usual care
- Outcome
- Cancer mortality
Methodological detailsrandom-effects model, general linear mixed model (GLMM), GRADE certainty assessment, trial sequential analysis, subgroup analysis by glycemic status
- Random-effects model
- General linear mixed model (GLMM)
- GRADE certainty assessment
- Trial sequential analysis
- Subgroup analysis by glycemic status
Pooled result
As reported in the abstract
Relative risk
0.94
95% CI 0.81–1.10
Lifestyle interventionsvs Usual care
RR 0.94 (95% CI 0.81–1.10)
Further pooled results
Trial sequential analysis
- Cumulative Z curve reached futility boundary; total number did not reach detection boundary
Original publication
Cancer Outcomes Among Prediabetes and Type 2 Diabetes Populations With Dietary and Physical Activity–based Lifestyle Interventions. J Clin Endocrinol Metab. Published 3 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →