Risk of dementia associated with body mass index, changes in body weight and waist circumference in older people with type 2 diabetes: The Edinburgh Type 2 Diabetes Study
Authors' conclusion
Both a lower BMI and weight loss over a period of years are indicative of increased dementia risk for older people with type 2 diabetes, while waist circumference changes may be less informative.
Study context
- Population
- Older men and women with T2D aged 60–75, Edinburgh Type 2 Diabetes Study105 dementia events
- Participants
- 1,064 men
- Exposure
- Body mass index (BMI) groups; body weight change >5% loss vs ≦5%
- Outcome
- Incident dementia
- Follow-up
- Median 10.84 years
Methodological detailscompeting-risk survival models
- Competing-risk survival models
Main finding
As reported in the abstract
Incident dementia by baseline BMI
Hazard ratio
0.44
P = 0.002
BMI 25-29.9 kg/m²
Hazard ratio
0.41
P = 0.001
BMI 30-34.9 kg/m²
Hazard ratio
0.35
P = 0.001
BMI ≧35 kg/m²
Observational data: associations, not effects.
Further findings
| Outcome | HR | P value |
|---|---|---|
| Incident dementia by body weight change over 4 years (weight change subgroup, n = 821; 78 events) · between years 4 and 10Weight loss >5% vs Weight loss ≦5% | 2.06 | P = 0.010 |
Waist circumference change and dementia
- The association between waist circumference change and dementia was not significant
Original publication
Risk of dementia associated with body mass index, changes in body weight and waist circumference in older people with type 2 diabetes: The Edinburgh Type 2 Diabetes Study. Diabet Med. Published 3 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →