Efficacy and Safety of Continuous Glucose Monitoring and Intermittently Scanned Continuous Glucose Monitoring in Patients With Type 2 Diabetes: A Systematic Review and Meta-analysis of Interventional Evidence
Authors' conclusion
Both CGM and isCGM demonstrated a reduction in HbA1c levels in individuals with T2D, and unlike CGM, isCGM use was associated with improved user satisfaction. The impact of these devices on body composition, blood pressure, and lipid levels remains unclear, while both CGM and isCGM use were associated with increased risk of adverse events.
Study context
- Population
- Patients with T2D in randomized controlled trials (RCTs) comparing at least two interventions for ≥8 weeks; searches to August 2023
- Participants
- 2,783 patients26 RCTs
- Comparison
- Continuous glucose monitoring (CGM) and intermittently scanned CGM (isCGM) vs usual care or self-monitoring of blood glucose (SMBG)
- CGMn = 632
- isCGMn = 871
- Usual care/SMBGn = 514reference
- Usual care/SMBGn = 766reference
- Outcome
- HbA1c
Pooled result
As reported in the abstract
Each group vs usual care/SMBGMean difference, % (95% CI)
CGM
−0.19(−0.34 to −0.04)
- isCGM
- −0.31 % (95% CI −0.46 to −0.17)
Further pooled results
| Outcome | Estimate |
|---|---|
| Glycemic medication effect scoreCGM vs Usual care/SMBG | −0.67 (CI −1.20 to −0.13) |
| User satisfactionCGM vs Usual care/SMBG · reduced with CGM | −0.54 (CI −0.98 to −0.11) |
| User satisfactionisCGM vs Usual care/SMBG · increased with isCGM | 0.44 (CI 0.29–0.59) |
CGM metrics, body composition, BP, lipids
- isCGM improved CGM metrics
- Neither CGM nor isCGM had a significant impact on body composition, BP or lipid levels
Safety
| Outcome | RR (95% CI) | |
|---|---|---|
| Adverse eventsCGMvs Usual care/SMBG | 1.22 (1.01–1.47) | |
| Adverse eventsisCGMvs Usual care/SMBG | 1.30 (0.05–1.62) | |
| 0.050.21520Relative risk (log scale) |
Original publication
Efficacy and Safety of Continuous Glucose Monitoring and Intermittently Scanned Continuous Glucose Monitoring in Patients With Type 2 Diabetes: A Systematic Review and Meta-analysis of Interventional Evidence. Diabetes Care. Published 20 December 2023. doi:10.
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