Continuous glucose monitoring in adults with type 2 diabetes: a systematic review and meta-analysis
Pooled result · HbA1cResult — go to the resultMD −3.43 mmol/mol 95% CI −4.75 to −2.11Authors' conclusion
CGM use compared with SMBG is associated with improvements in glycaemic control in adults with type 2 diabetes. However, all studies were open label. In addition, outcome data on incident severe hypoglycaemia and incident microvascular and macrovascular complications were scarce.
Study context
- Population
- Adults with T2D; RCTs with intervention duration ≥6 weeks; searches to 2 May 2023
- Participants
- 1,248 adults12 RCTs
- Comparison
- Continuous glucose monitoring (CGM) vs self-monitoring of blood glucose (SMBG)
- Outcome
- Change in HbA1c
Methodological detailsCochrane risk-of-bias tool version 2, All studies were open label
- Cochrane risk-of-bias tool version 2
- All studies were open label
Pooled result
HbA1c
MD
−3.43 mmol/mol
95% CI −4.75 to −2.11
P < 0.00001
CGMvs SMBG
MD −3.43 mmol/mol (95% CI −4.75 to −2.11); P < 0.00001
As reported in the abstract
Further pooled results
| Outcome | MD (mmol/mol) (95% CI) | P value | |
|---|---|---|---|
| HbA1c, subgroup insulin with or without oral agents−0.30%; I2=55% | −3.27 (−6.22 to −0.31) | P = 0.03 | |
| HbA1c, subgroup oral agents only−0.29%; I2=0% | −3.22 (−5.39 to −1.05) | P = 0.004 | |
| HbA1c, rtCGMvs SMBG−0.36%; I2=0%; trend towards larger effect than isCGM | −3.95 (−5.46 to −2.44) | P < 0.00001 | |
| HbA1c, isCGMvs SMBG−0.16%; I2=64% | −1.79 (−5.28 to 1.69) | P = 0.31 | |
| −10−505Difference, mmol/mol (linear scale) |
| Outcome | Difference (%) (95% CI) | P value | |
|---|---|---|---|
| TBRI2=45% | −0.66 (−1.21 to −0.12) | P = 0.02 | |
| TARI2=37% | −5.86 (−10.88 to −0.84) | P = 0.02 | |
| Glycaemic variabilityI2=0% | −1.47 (−2.94 to −0.01) | P = 0.05 | |
| −15−10−505Difference, % (linear scale) |
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| Macrovascular complicationsI2=29%; non-statistically significant | 1.54 (0.42–5.72) | P = 0.52 | |
| 0.20.5125Relative risk (log scale) |
| Outcome | Difference (%) (95% CI) | P value |
|---|---|---|
| TIRI2=9% | +6.36 (+2.48, +10.24) | P = 0.001 |
Macrovascular complications
- No trials reported data on microvascular complications
Safety
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| Severe hypoglycaemiaI2=0%; non-statistically significant | 0.66 (0.15–3.00) | P = 0.57 | |
| 0.10.31310Relative risk (log scale) |
Original publication
Continuous glucose monitoring in adults with type 2 diabetes: a systematic review and meta-analysis. Diabetologia. Published 16 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →