Incidence and Characteristics of the Hyperosmolar Hyperglycemic State: A Danish Cohort Study
Authors' conclusion
The incidence of HHS was higher among patients with type 1 diabetes compared with type 2 diabetes. HHS is a spectrum of hyperglycemic crises and can be divided in pure HHS and HHS-DKA. In one-third of patients, HHS was the debut of their diabetes diagnosis.
Study context
- Population
- Acutely admitted adults (≥18 years) in Denmark, 2016–2018, meeting hyperosmolar hyperglycemic state (HHS) criteria (glucose ≥33 mmol/L and osmolarity ≥320 mmol/L); median age 69 years
- Participants
- 24,196 vs 251,357
- Exposure
- Known T1D vs known T2D
- T1Dn = 24,196
- T2Dn = 251,357
- Outcome
- Incidence of HHS
Methodological detailsregistry-based
- Registry-based
Main finding
As reported in the abstract
Incidence rate of HHS
T1D
16.5 per 10,000 person-years
T2D
3.9 per 10,000 person-years
Observational data: associations, not effects.
Further findings
In-hospital mortality by HHS category
- In-hospital mortality by HHS category — Pure HHS n
- 394
- In-hospital mortality by HHS category — HHS-DKA n
- 240
HHS patients not previously diagnosed with diabetes
- Not previously diagnosed with diabetes
- 32%
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Incidence and Characteristics of the Hyperosmolar Hyperglycemic State: A Danish Cohort Study. Diabetes Care. Published 12 December 2023. doi:10.
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