Importance of beta cell mass for glycaemic control in people with type 1 diabetes
Authors' conclusion
Our data show higher beta cell mass in people with type 1 diabetes and LGV than in those with HGV, independent of beta cell function.
Study context
- Population
- People with T1D
- Participants
- 9 vs 7
- Exposure
- Low glucose variability vs high glucose variability
- Low glucose variability (LGV)n = 9
- High glucose variability (HGV)n = 7reference
- Outcome
- Beta cell mass: pancreatic SUVmean of radiolabelled exendin on PET
Methodological detailsPositron emission tomography (PET) imaging with [68Ga]Ga-NODAGA-exendin-4
- PET imaging with [68Ga]Ga-NODAGA-exendin-4
Main finding
As reported in the abstract
Pancreatic SUVmean
LGV
5.1
range or IQR as printed 3.6–5.6
HGV
2.9
range or IQR as printed 2.1–3.4
P = 0.008
Observational data: associations, not effects.
Further findings
HbA1c · lower with LGV
P = 0.001
HbA1c % LGV 6.4% (6.3-7) · HGV 9.5% (8.5-12.2)
| Outcome | LGV | HGV | P value |
|---|---|---|---|
| TIRHigher with LGV | 75.6% (range or IQR as printed 73.5–90.3) | 38.7% (range or IQR as printed 25.1–48.5) | P = 0.002 |
| AUC C-peptide:AUC glucose ratio (beta cell function)Numerically, not statistically, higher with LGV | 2.7×10-2 (range or IQR as printed 6.2×10-4-5.3×10-2) | 9.3×10-4 (range or IQR as printed 4.7×10-4-5.2×10-3) | P = 0.21 |
Correlations of SUVmean
- SUVmean vs AUC C-peptide:AUC glucose ratio, Pearson r
- 0.64 (p=0.01)
- SUVmean vs time in range (TIR), r
- 0.64 (p=0.01)
- SUVmean vs SD of interstitial glucose, r
- −0.66 (p=0.007)
Original publication
Importance of beta cell mass for glycaemic control in people with type 1 diabetes. Diabetologia. Published 17 November 2022. doi:10.
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