Implications of the use of 1-hour post-load plasma glucose value during an oral glucose tolerance test (OGTT) for the diagnosis of dysglycemia among a cohort of high-risk Thai people
Authors' conclusion
Diabetes prevalence is more than 2 times higher when diagnosed with the IDF OGTT criteria in high-risk Thai people. Overt DM by the IDF OGTT would be missed for almost 5 times by using the HbA1c level alone.
Study context
- Population
- High-risk Thai people who underwent OGTT in routine clinical setting; age 50.3 ± 13.0 years, BMI 26.3 ± 4.9 kg/m², HbA1c 5.7 ± 0.5 %
- Participants
- 1,203 people
- Exposure
- International Diabetes Federation (IDF) 1-h PG OGTT criteria vs traditional OGTT criteria
- Outcome
- Prevalence of dysglycemia
Methodological details18-year, routine clinical setting
- 18-year
- Routine clinical setting
Main finding
As reported in the abstract
- Impaired glucose tolerance (IGT) by traditional OGTT criteria
- 36.6 %
- DM by traditional OGTT criteria
- 16.8 %
- Elevated 1-h PG among normal glucose tolerance (NGT)
- 40.6 %
- NGT classified as DM by IDF OGTT criteria
- 3.4 %
- IGT classified as DM by IDF criteria
- 40.9 %
Observational data: associations, not effects.
Further findings
Optimal HbA1c cut-off to diagnose DM, with 1-h OGTT criteria as reference standard
- Optimal HbA1c cut-off, much lower than current HbA1c-based DM criteria
- 5.9 %
Original publication
Implications of the use of 1-hour post-load plasma glucose value during an oral glucose tolerance test (OGTT) for the diagnosis of dysglycemia among a cohort of high-risk Thai people. Diabetes Res Clin Pract. Published 21 February 2025. doi:10.
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