One-hour post-load plasma glucose thresholds for intermediate hyperglycemia and type 2 diabetes mellitus diagnosis in the Chinese population
Authors' conclusion
In the Chinese population, the optimal 1-h PG thresholds for IH and T2DM were 9.63 mmol/L and 13.04 mmol/L, respectively, indicating the best balance between specificity and sensitivity.
Study context
- Population
- Chinese participants across the spectrum of glucose tolerance
- Participants
- 927 participants
- Comparison
- 1-h PG thresholds vs traditional OGTT criteria
- Outcome
- Optimal 1-h PG cutoff values for intermediate hyperglycemia (IH) and T2D based on maximum Youden index
Performance
As reported in the abstract
Optimal 1-h PG cutoffs
Optimal 1-h PG cutoff for intermediate hyperglycemia (IH)
9.63 mmol/L
Optimal 1-h PG cutoff for diabetes
13.04 mmol/L
Further findings
Agreement between 1-h PG thresholds and traditional OGTT criteria
- Strong agreement, weighted Cohen's κ
- 0.600 (95% CI 0.553-0.646)
Insulin levels in normal glucose tolerance
- Among those with normal glucose tolerance, elevated 1-h PG was associated with higher insulin levels under glucose stimulation
Original publication
One-hour post-load plasma glucose thresholds for intermediate hyperglycemia and type 2 diabetes mellitus diagnosis in the Chinese population. Diabetes Res Clin Pract. Published 1 December 2025. doi:10.
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