Impact of patient characteristic factors on the dynamics of liver glucose metabolism: Evaluation of multiparametric imaging with dynamic whole‐body 18 F‐fluorodeoxyglucose‐positron emission tomography
Authors' conclusion
Our results showed that liver glucose metabolism was influenced by various patient characteristic factors. Multiparametric FDG-PET imaging can be used to analyse the kinetics of liver glucose metabolism in routine clinical practice.
Study context
- Population
- Patients who underwent whole-body dynamic FDG-PET
- Participants
- 540 patients
- Outcome
- Correlates of hepatic glucose metabolism indices (multiple regression)
Methodological detailsmultiple regression analysis
- Multiple regression analysis
Main finding
As reported in the abstract
- Hepatic SULmean correlated with age
- p < .001
- Hepatic SULmean correlated with sex
- p < .001
- Hepatic SULmean correlated with blood glucose level
- p = .002
- Distribution volume (DV) correlated with age
- p = .033
- DV correlated with sex
- p < .001
- DV correlated with BMI
- p = .002
- DV correlated with fasting time
- p = .043
- DV correlated with presence of hepatic steatosis (HS)
- p = .002
- Kinetic index correlated with age
- p < .001
- Kinetic index correlated with sex
- p = .004
Observational data: associations, not effects.
Further findings
Success rate of kinetic analysis
- Success rate of kinetic analysis using multiparametric positron emission tomography (PET) imaging
- 93.3% (504/540)
Healthy vs diabetes mellitus (DM) vs HS groups
- Patients with DM had significantly increased SULmean
- Patients with HS had significantly decreased DV
Original publication
Impact of patient characteristic factors on the dynamics of liver glucose metabolism: Evaluation of multiparametric imaging with dynamic whole‐body 18 F‐fluorodeoxyglucose‐positron emission tomography. Diabetes Obes Metab. Published 17 August 2023. doi:10.
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