Impact of youth onset type 2 diabetes during pregnancy on microvascular and cardiac outcomes
Main finding · Hyperfiltration (eGFR ≥135 ml/min/1.73 m²)Result — go to the resultFold increased risk (Cox regression) 2.76 CI 1.38–5.49Authors' conclusion
These results indicate that pregnancy increases the risk of hyperfiltration in women with youth-onset T2D, but not other micro or macrovascular complications. The rates of vascular complications are very high in youth-onset T2D potentially obscuring micro- and macrovascular changes attributable to pregnancy.
Study context
- Population
- Women with youth-onset T2D in the TODAY study
- Participants
- 116 vs 291
- Exposure
- Pregnancy of ≥20 weeks gestation vs no pregnancy
- Pregnancyn = 116
- No pregnancyn = 291reference
- Outcome
- Hyperfiltration (eGFR ≥135 ml/min/1.73 m²)
Methodological detailssecondary analysis of the TODAY study
- Secondary analysis of the TODAY study
Main finding
As reported in the abstract
Fold increased risk (Cox regression)
2.76
CI 1.38–5.49
P = 0.004
Observational data: associations, not effects.
Further findings
Retinopathy
Neuropathy
Retinopathy
- No differences observed
Neuropathy
- No differences observed
Echocardiographic and arterial stiffness changes
- In fully adjusted models, pregnancy did not impact changes vs never pregnant
Original publication
Impact of youth onset type 2 diabetes during pregnancy on microvascular and cardiac outcomes. Diabetes Res Clin Pract. Published 16 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →