Associations between cardiac adipose tissue volume, measures of coronary calcification, myocardial microvascular function and systemic inflammation in individuals with type 2 diabetes free of overt cardiovascular disease
Authors' conclusion
In individuals with T2D without overt CVD, PEAT volume was not independently associated with CACS or MFR after multivariable adjustment. Higher PEAT volume was associated with higher hsCRP, suggesting a relationship with systemic inflammation
Study context
- Population
- Adults with T2D without overt CVD, recruited 2020–2023; mean age 65 years, 70% male, mean BMI 30 kg/m²
- Participants
- 887 adults
- Exposure
- Higher vs lower peri- and epicardial adipose tissue (PEAT) volume
- Outcome
- Associations of PEAT (per 100 mL) with MFR, hsCRP and CACS >300
Methodological detailsPEAT on non-contrast CT; CACS by Agatston method; Myocardial flow reserve (MFR) by rubidium-82 PET/CT, Multivariable regression adjusting for cardiovascular risk factors
- PEAT on non-contrast CT; CACS by Agatston method; MFR by rubidium-82 PET/CT
- Multivariable regression adjusting for cardiovascular risk factors
Main finding
As reported in the abstract
- Median PEAT volume (IQR 133-283)
- 199 mL
- MFR, β per 100 mL PEAT (95% CI - 0.09 to 0.00; p = 0.041), age- and sex-adjusted
- - 0.04
- hsCRP increase per 100 mL PEAT (95% CI 28% to 48%; p < 0.001), age- and sex-adjusted
- 38%
- CACS > 300, OR per 100 mL PEAT (95% CI 0.89-1.15), age- and sex-adjusted
- 1.01
- After multivariable adjustment, only the association with hsCRP remained significant
- 14% (CI 4% to 25%; p = 0.005)
Observational data: associations, not effects.
Original publication
Associations between cardiac adipose tissue volume, measures of coronary calcification, myocardial microvascular function and systemic inflammation in individuals with type 2 diabetes free of overt cardiovascular disease. Cardiovasc Diabetol. Published 23 July 2026. doi:10.
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