Elevated whole blood viscosity is associated with an impaired insulin-stimulated myocardial glucose metabolism
Authors' conclusion
The current study showed a strongly association between an increase of WBV and an impaired myocardial glucose metabolism in individuals with a broad spectrum of glucose tolerance.
Study context
- Population
- Individuals with different glucose tolerance status; myocardial MRGlu by dynamic cardiac 18F-FDG PET with euglycemic hyperinsulinemic clamp; Whole blood viscosity (WBV) calculated from hematocrit and plasma proteins
- Participants
- 57 individuals
- Exposure
- Lowest vs highest myocardial MRGlu tertile
- Outcome
- Association between WBV and myocardial glucose metabolic rate (MRGlu)
Main finding
As reported in the abstract
WBV (age-adjusted)
P = 0.001
- Correlation of WBV with myocardial MRGlu
- r = - 0.416, P = 0.001
Observational data: associations, not effects.
Further findings
Hematocrit (age-adjusted)
P = 0.004
Total proteins (age-adjusted)
P < 0.0001
Stepwise multivariate regression: variables associated with myocardial MRGlu
- WBV
- β - 0.505; P < 0.0001
- Fasting insulin
- β - 0.346; P = 0.004
- FPG
- β - 0.287; P = 0.01
- Sex
- β 0.280; P = 0.003
- Variation explained
- 69.6%
Original publication
Elevated whole blood viscosity is associated with an impaired insulin-stimulated myocardial glucose metabolism. Cardiovasc Diabetol. Published 4 December 2024. doi:10.
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