Impact of Insulin-Induced Relative Hypoglycemia on Vascular Insulin Sensitivity and Central Hemodynamics in Prediabetes
Authors' conclusion
Compared with normoglycemia, insulin-induced RH corresponded with a blunted rise in heart rate and drop in Pf during insulin infusion in adults with prediabetes, independent of changes in peripheral endothelial function.
Study context
- Population
- Adults with obesity, classified by ADA criteria as prediabetes or normoglycemia
- Participants
- 70 adults
- Comparison
- Prediabetes vs normoglycemia
- Prediabetesn = 34
- Normoglycemian = 36reference
- Outcome
- Relative hypoglycemia: drop in glucose from fasting to clamp steady state
Methodological detailseuglycemic clamp
- Euglycemic clamp
Main finding
As reported in the abstract
P = 0.03
- Heart rate increased in normoglycemia vs prediabetes
- P < 0.01
- Forward wave (Pf) decreased in prediabetes
- P = 0.04
- Insulin tended to reduce arterial stiffness in normoglycemia vs prediabetes
- P = 0.07
- Similar increases in preocclusion diameter
- P = 0.02
- Similar increases in blood flow
- P = 0.02
- Lower augmentation index
- P ≤ 0.05
Further findings
| Outcome | P value |
|---|---|
| Baseline characteristicsHigher HbA1c with prediabetes | P < 0.01 |
Baseline characteristics
- No differences in age, weight, or VO2max between groups
Original publication
Impact of Insulin-Induced Relative Hypoglycemia on Vascular Insulin Sensitivity and Central Hemodynamics in Prediabetes. J Clin Endocrinol Metab. Published 16 March 2024. doi:10.
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