Impact of diabetes on proteomic changes in circulating extracellular vesicles in individuals with obesity before and after bariatric surgery
Authors' conclusion
Diabetes affects the differences in EV protein profiles in patients with obesity before and after bariatric surgery. These DEPs may serve as potential biomarkers and therapeutic targets for obesity-related diabetes.
Study context
- Population
- Patients with obesity, with and without diabetes, undergoing bariatric surgery, and healthy controls30 with obesity, 37 controls
- Exposure
- Obesity with vs without diabetes, vs healthy controls; before vs 6 months after bariatric surgery
- Healthy controlsn = 37reference
- Outcome
- Differentially expressed serum EV proteins (DEPs)
Methodological detailsproteomic (liquid chromatography-tandem mass spectrometry)
- Proteomic (liquid chromatography-tandem mass spectrometry)
Main finding
As reported in the abstract
Differentially expressed proteins (DEPs) in extracellular vesicles (EVs), healthy controls vs obesity
19
DEPs, obesity with vs without diabetes
20
DEPs after bariatric surgery in obesity with diabetes, mainly immune system
14
DEPs after bariatric surgery in obesity without diabetes, predominantly reactive oxygen species metabolism
13
Observational data: associations, not effects.
Original publication
Impact of diabetes on proteomic changes in circulating extracellular vesicles in individuals with obesity before and after bariatric surgery. Int J Obes (Lond). Published 17 July 2025. doi:10.
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