Effects of Bariatric Surgery on Blood and Vascular Large Extracellular Vesicles According to Type 2 Diabetes Status
Authors' conclusion
At 1 year after BS, lEV concentrations remain above the physiological range. These abnormalities might contribute to explaining the increased CV risk after BS and underscore the importance of long-term CV risk factor control in post-BS individuals.
Study context
- Population
- Individuals with obesity eligible for bariatric surgery, with or without T2D, and normal-weight controls; age 48.0 ± 10.5 years; 84.3% females
- Participants
- 108 individuals
- Exposure
- Obesity with or without T2D before vs 1 year after bariatric surgery, and vs normal-weight controls
- Outcome
- Concentration and phenotype of large extracellular vesicles (lEVs) by flow cytometry
- Follow-up
- Before and 1 year after BS
Methodological detailscontrols matched by age and sex
- Controls matched by age and sex
Main finding
As reported in the abstract
lEVs enriched for endothelial and blood cell markers
- Bariatric surgery (BS) significantly reduced most large extracellular vesicles (lEVs) enriched for cell-specific markers in both OB and T2D
- OB vs HC: P < 0.05
- OB vs T2D: P < 0.05
- OB vs T2D: P > 0.05
- OB vs HC: P < 0.05
- T2D vs HC: P < 0.05
Observational data: associations, not effects.
Original publication
Effects of Bariatric Surgery on Blood and Vascular Large Extracellular Vesicles According to Type 2 Diabetes Status. J Clin Endocrinol Metab. Published 17 August 2023. doi:10.
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