Impact of cumulative hyperglycemic burden on the pancreatic cancer risk: A nationwide cohort study
Authors' conclusion
The pancreatic cancer incidence increased significantly according to the hyperglycemic burden, defined as sustained hyperglycemic exposure, including pre-diabetic levels.
Study context
- Population
- Individuals with four consecutive annual health screenings 2009–2013, National Health Insurance Service Database
- Participants
- 3,138,099 individuals
- Exposure
- Hyperglycemic burden 1–4 vs normal
- Outcome
- Pancreatic cancer risk
- Follow-up
- Median 6.2 years
Main finding
As reported in the abstract
Pancreatic cancer risk vs normal subjects · median 6.2 years
Burden 1: increased risk
15%
Burden 2: increased risk
30%
Burden 3: increased risk
26%
Burden 4: increased risk
67%
Observational data: associations, not effects.
Further findings
Semiquantitative score (pre-diabetic 1 point, diabetic 2 points; score 0–8)
- Pre-diabetic glucose on ≥1 occasion: increased risk
- 14%
- Score 8 vs normal range: higher risk
- 89%
Original publication
Impact of cumulative hyperglycemic burden on the pancreatic cancer risk: A nationwide cohort study. Diabetes Res Clin Pract. Published 10 December 2022. doi:10.
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