Cumulative exposure to hypertriglyceridemia and risk of type 2 diabetes in young adults
Authors' conclusion
In this large-scale prospective cohort study of young adults, cumulative exposure to hypertriglyceridemia was significantly associated with an increased risk of type 2 diabetes, independent of lifestyle-related factors.
Study context
- Population
- Young adults aged 20–39 years with four consecutive annual health checkups and no history of T2D
- Participants
- 1,840,251 adults
- Exposure
- Cumulative exposure to hypertriglyceridemia vs score 0
- Outcome
- Newly diagnosed T2D
- Follow-up
- 6.53 years
Methodological detailslarge-scale
- Large-scale
Main finding
As reported in the abstract
Incident T2D
Multivariable-adjusted HR (95 % CI)
Exposure score onevs Exposure score 0
1.674(1.619–1.732)
Exposure score twovs Exposure score 0
2.192(2.117–2.269)
Exposure score threevs Exposure score 0
2.637(2.548–2.73)
Exposure score fourvs Exposure score 0
3.715(3.6–3.834)
- Developed T2D (all participants)
- 40,286
- Cumulative incidence of T2D significantly increased with higher exposure scores (log-rank test)
- P < 0.001
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Cumulative exposure to hypertriglyceridemia and risk of type 2 diabetes in young adults. Diabetes Res Clin Pract. Published 21 January 2024. doi:10.
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