Impact of an Advanced Hybrid Closed-Loop System on Glycemic Control Throughout the Menstrual Cycle in Women with Type 1 Diabetes Prone to Hypoglycemia
Authors' conclusion
In conclusion, AHCL improved glycemic control throughout the MC, but performance differed according to phase.
Study context
- Population
- Women with T1D prone to hypoglycaemia; 39 pairs of spontaneous menstrual cycles39 pairs of cycles
- Participants
- 13 women
- Exposure
- Advanced hybrid closed loop (AHCL) vs sensor-augmented pump, across menstrual cycle phases
- Outcome
- Glycaemic control throughout the menstrual cycle
Main finding
As reported in the abstract
Baseline TBR <70: midfollicular vs late luteal phase (significantly higher midfollicular)
5.7% ± 5.0% vs. 4.1% ± 3.0%
After AHCL, pre-existing phase differences in TBR <70 eradicated
3.5% ± 3.2% vs. 3.0% ± 3.0%
After AHCL, TIR significantly higher in early follicular than late luteal phase
79.1% ± 9.3% vs. 74.5% ± 10.0%
Observational data: associations, not effects.
Further findings
- Phase-dependent changes in insulin infusion detected
Original publication
Impact of an Advanced Hybrid Closed-Loop System on Glycemic Control Throughout the Menstrual Cycle in Women with Type 1 Diabetes Prone to Hypoglycemia. Diabetes Technol Ther. Published 10 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →