Gastric emptying in newly diagnosed, treatment‐naïve Han Chinese with type 2 diabetes and the impact of 4‐week insulin pump therapy
Authors' conclusion
In newly diagnosed Han Chinese with T2D, GE is often accelerated despite poor glycaemic control and is slowed by short-term insulin pump therapy. The effect on GE is maintained for at least 12 months.
Study context
- Population
- Newly diagnosed, treatment-naïve Han Chinese with T2D; baseline HbA1c 10.7% (SD 1.2%), 93 (SD 10) mmol/mol
- Exposure
- Newly diagnosed T2D before vs after 4 weeks of insulin pump therapy, and vs healthy participants
- T2Dn = Twenty
- Healthyn = 19reference
- Outcome
- GE (gastric half-emptying time, 13C-acetate) and glycaemic response to a 75-g oral glucose load
- Follow-up
- Before, after 4 weeks of insulin pump therapy, and 12-15 months after
Methodological detailshealthy controls matched for sex and age, before-after comparison, insulin pump therapy discontinued for 48 h before re-assessment
- Healthy controls matched for sex and age
- Before-after comparison
- Insulin pump therapy discontinued for 48 h before re-assessment
Main finding
As reported in the abstract
- At baseline, T2D vs healthy: augmented fasting and post-glucose glycaemia, diminished insulin secretion, more rapid gastric emptying (GE) (p < 0.05 each); comparable GLP-1
- After insulin pump therapy: insulin secretion increased, GLP-1 secretion attenuated, fasting and post-glucose glycaemia lower, GE slowed (p < 0.05 each)
Observational data: associations, not effects.
Further findings
GE at 12-15 months follow-up
- Slowing of GE in T2D sustained over 12-15 months
- Re-measured in 14 of the T2D participants
Original publication
Gastric emptying in newly diagnosed, treatment‐naïve Han Chinese with type 2 diabetes and the impact of 4‐week insulin pump therapy. Diabetes Obes Metab. Published 2 May 2024. doi:10.
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