Impact of Missed and Late Meal Boluses on Glycemic Outcomes in Automated Insulin Delivery-Treated Children and Adolescents with Type 1 Diabetes: A Two-Center, Population-Based Cohort Study
Main finding · TIR (70-180 mg/dL)Result — go to the resultDifference 22.9 % 95% CI 27.2–18.6Authors' conclusion
MLBs significantly impacted glycemic outcomes in AID-treated children and adolescents.
Study context
- Population
- Automated insulin delivery (AID)-treated (Tandem Control-IQ or Medtronic MiniMed 780G) children and adolescents aged 6–21 years with T1D and ≥10 days of data, Stanford Medical Center and Steno Diabetes Center Copenhagen; 48% females, mean age 13 ± 4 years
- Participants
- 189 participants
- Exposure
- Quartile with most meal boluses (MLBs) vs quartile with fewest MLBs
- Outcome
- Association between the number of algorithm-detected missed or late meal boluses (MLBs) and TIR (70-180 mg/dL)
Methodological detailstwo-center, binational, population-based, 1-month
- Two-center
- Binational
- Population-based
- 1-month
Main finding
TIR (70-180 mg/dL)
Difference
22.9 %
95% CI 27.2–18.6
As reported in the abstract
- TIR decrease for each additional MLB per day
- 9.7% points (95% CI 11.3; 8.1)
- Mean number of MLBs per day in the cohort
- 2.2 ± 0.9
Observational data: associations, not effects.
Further findings
Age-, sex- and treatment modality-adjusted probability of achieving TIR >70%
P < 0.001
Original publication
Impact of Missed and Late Meal Boluses on Glycemic Outcomes in Automated Insulin Delivery-Treated Children and Adolescents with Type 1 Diabetes: A Two-Center, Population-Based Cohort Study. Diabetes Technol Ther. Published 24 June 2024. doi:10.
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