Beneficial effects of automated insulin delivery over one‐year follow‐up in real life for youths and adults with type 1 diabetes irrespective of patient characteristics
Authors' conclusion
This analysis showed the beneficial effects of two AID systems for people with type 1 diabetes across a broad spectrum of participant characteristics. Only half of the participants achieved international recommendations for glucose control with TIR70-180 mg/dl >70%, HbA1c levels or GMI <7%, which outlines the need to maintain strong educational and individual strategies.
Study context
- Population
- Youths and adults with T1D (48 adolescents, 183 adults; 55% females; aged 10–77 years) initiating automated insulin delivery (AID) at a specialized university T1D centre, observed 3–12 months48 adolescents · 183 adults
- Exposure
- AID systems: follow-up vs baseline
- Outcome
- TIR70-180 mg/dl by CGM, mean GMI and HbA1c
Methodological detailsreal-world, observational, single-centre
- Real-world
- Observational
- Single-centre
Main finding
As reported in the abstract
Mean TIR70-180 mg/dl after 360 days (95% CI 69.4-73.2), n = 123, p < .001
71.33%
Increase in TIR70-180 mg/dl vs baseline after 360 days
14% points
HbA1c decrease after 360 days
0.7%
Glucose management indicator (GMI) decrease after 360 days
0.6%
Observational data: associations, not effects.
Further findings
Time <70 mg/dl (3.9 mmol/L)
- Not significantly different from baseline
780G vs Control-IQ · during follow-up
- 780G users had better CGM results than Control-IQ users but similar HbA1c levels
Clinical factors and TIR70-180 mg/dl
- Age at onset influenced TIR in univariate analysis but no significant relationship after adjustment
- Baseline BMI did not influence AID performance
Safety
Weight gain · during follow-up
- Increased risk of weight gain with 780G vs Control-IQ
Original publication
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