Impact of glycemic optimization on myocardial steatosis and cardiac remodeling in patients with newly diagnosed type 2 diabetes: a longitudinal study
Authors' conclusion
In patients with newly diagnosed T2D, 12 months of glycemic optimization was associated with changes in cardiac remodeling parameters despite no detectable changes in myocardial steatosis. The observed cardiac changes were more closely associated with concurrent reductions in adiposity markers than with changes in HbA1c, emphasizing weight management as a key target for early prevention of diabetic cardiomyopathy.
Study context
- Population
- Adults with newly diagnosed T2D; mean age 54.8 ± 9 years, 72.3% male
- Participants
- 20 adults
- Exposure
- 12 months of glycaemic optimization vs baseline
- Outcome
- Longitudinal changes in myocardial triglyceride content (MTGC) and cardiac remodeling (CMR, ¹H-MRS)
- Follow-up
- 12 months
Main finding
As reported in the abstract
- No significant changes in myocardial triglyceride content (MTGC) at follow-up
- 12 months vs Baseline: P = 0.23
Observational data: associations, not effects.
Further findings
Left ventricle (LV) ejection fraction · baseline to 12 months
- LV ejection fraction increased
- P = 0.01
LV end-systolic volume · baseline to 12 months
- LV end-systolic volume decreased
- P = 0.007
Right ventricular (RV) end-systolic volume · baseline to 12 months
- RV end-systolic volume decreased
- P = 0.02
RV end-diastolic volume · baseline to 12 months
- RV end-diastolic volume decreased
- P = 0.03
Indexed LV mass · baseline to 12 months
- Indexed LV mass increased
- P = 0.006
HbA1c, body mass index (BMI) and waist circumference (WC) · 12 months
- Significant reductions in HbA1c, BMI and WC
Associations of HbA1c improvement with MTGC or CMR parameters
- No associations between HbA1c improvement and MTGC or CMR parameters
Associations of adiposity reductions with cardiac parameters
- Reductions in BMI and WC associated with greater left atrial strain (ρ)
- - 0.78 and - 0.77; p < 0.001
- Reductions in WC associated with greater LV end-diastolic volume (ρ)
- −0.59; p = 0.024
Original publication
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