Hypogonadism and neurocognitive outcomes among childhood cancer survivors
Main finding · Impaired visual processing speedResult — go to the resultRelative risk 1.7 95% CI 1.2–2.5Authors' conclusion
Processing speed may be the most vulnerable neurocognitive domain associated with hypogonadism in survivors, while other domains were mainly impacted by cancer-related variables. Our findings support the need for further evaluation of the impact of sex hormone replacement therapy on neurocognitive function.
Study context
- Population
- Childhood cancer survivors who completed standard neurocognitive tests (6 domains) and self-reported emotional distress; stratified by sex and gonadal status
- Participants
- 3,628 survivors
- Exposure
- Hypogonadal vs eugonadal survivors
- Outcome
- Neurocognitive impairment (processing speed, memory, executive function, attention, academics, global cognition) and emotional distress
Methodological detailsretrospective cohort, multivariable analysis, mediation analyses
- Retrospective cohort
- Multivariable analysis
- Mediation analyses
Main finding
Impaired visual processing speed
Relative risk
1.7
95% CI 1.2–2.5
Hypogonadal femalesvs Eugonadal females
RR 1.7 (95% CI 1.2–2.5)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Mediation analyses: impact of hypogonadism on processing speed
- Females, visual processing speed: direct effect
- P < 0.01
- Females, visual processing speed: indirect effect
- from P < .01
- Males, motor processing speed: direct effect
- P = 0.03
- Males, motor processing speed: indirect effect
- P = 0.04
Original publication
Hypogonadism and neurocognitive outcomes among childhood cancer survivors. Eur J Endocrinol. Published 12 March 2024. doi:10.
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