Reversal of Congenital Hypogonadotropic Hypogonadism
Authors' conclusion
The reversal phenomenon in males has expanded our understanding of the regulation of human reproduction-yet precise mechanism(s) have yet to be elucidated. Clinicians can use clinical signs and genetic testing to identify patients who may benefit from close surveillance of reversal. Insights from reversal of CHH reversal have helped shape the first tailored approach managing CHH.
Study context
- Population
- Males with congenital hypogonadotropic hypogonadism (CHH) reported with reversal31 articles
- Outcome
- Reversal of CHH in males
Methodological detailsmini-review, structured, systematic literature search, Literature searched up to 2025
- Mini-review
- Structured, systematic literature search
- Literature searched up to 2025
Pooled result
As reported in the abstract
- Articles reporting reversal of CHH in males, incl. severe GnRH deficiency and pathogenic variants in CHH genes
- 31
Original publication
Reversal of Congenital Hypogonadotropic Hypogonadism. J Clin Endocrinol Metab. Published 5 November 2025. doi:10.
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