Incomplete Evidence of Bone Density Normalization Following Long-Term Reproductive Hormone Treatment in Men With Hypogonadotropic Hypogonadism
Pooled result · LS BMD, HH vs healthy controls (meta-analysis of 5 studies)Result — go to the resultSMD −5.98 95% CI −11.5 to −0.47Authors' conclusion
Men with HH have low BMD that improves with reproductive hormone treatment. However, current evidence suggests that incomplete BMD normalization may be common despite long-term reproductive hormone treatment in men with HH, particularly those with CHH.
Study context
- Population
- Men with hypogonadotropic hypogonadism (HH) (congenital or acquired), studies reporting bone mineral density (BMD) or fractures
- Participants
- 625 men24 studies
- Comparison
- Men with HH vs healthy controls
- Outcome
- Effect of reproductive hormone treatment on BMD
Methodological detailsmeta-regression
- Meta-regression
Pooled result
As reported in the abstract
LS BMD, HH vs healthy controls (meta-analysis of 5 studies)
SMD
−5.98
95% CI −11.5 to −0.47
HHvs Healthy controls
SMD −5.98 (95% CI −11.5 to −0.47)
Further pooled results
- Men with HH had low lumbar spine (LS) and femoral neck BMD, improving with hormonal treatment
- Men with CHH may have persistently low BMD despite prolonged hormonal treatment
- Higher BMD associated with younger age at treatment initiation, partial HH, and higher serum testosterone and estradiol
Original publication
Incomplete Evidence of Bone Density Normalization Following Long-Term Reproductive Hormone Treatment in Men With Hypogonadotropic Hypogonadism. J Clin Endocrinol Metab. Published 1 October 2025. doi:10.
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