Gestational diabetes & diabetes in pregnancy
Hypertensive disorders of pregnancy and gestational diabetes mellitus and predicted risk of maternal cardiovascular disease 10–14 years after delivery: A prospective cohort
Authors' conclusion
Individuals who experienced HDP or GDM had a higher predicted 10- and 30-year risk of ASCVD measured 10-14 years after delivery compared with individuals who did not experience these APOs.
Study context
- Population
- Pregnant individuals in the Hyperglycemia and Adverse Pregnancy Outcome Follow-up Study (2013–2016); median age 30.5 years, median gestational age 27.9 weeks at enrollment; 10.7% developed hypertensive disorders of pregnancy (HDP), 13.7% gestational diabetes mellitus (GDM)
- Participants
- 4,432 individuals
- Comparison
- HDP vs no HDP; GDM vs no GDM
- Primary endpoint
- 10- and 30-year predicted risk of ASCVD (composite of fatal and non-fatal coronary heart disease and stroke) by Framingham Risk Score, continuous
- Follow-up
- 10-14 years after delivery
Methodological detailsinternational
- International
Primary result
As reported in the abstract
Predicted ASCVD risk (least squares mean)
- HDP vs No HDP · 10-year: 2.9% vs. 2.2%
- adj. β (10-year risk) 0.59 (95% CI 0.41–0.77)
- HDP vs No HDP · 30-year: 7.7% vs. 6.1%
- adj. β (30-year risk) 1.27 (95% CI 0.81–1.72)
- GDM vs No GDM · 10-year: 3.2% vs. 2.1%
- adj. β (10-year risk) 0.51 (95% CI 0.34–0.67)
- GDM vs No GDM · 30-year: 8.8% vs. 5.8%
- adj. β (30-year risk) 1.56 (95% CI 1.11–2.01)
Further findings
Predicted atherosclerotic cardiovascular disease (ASCVD) risk at thresholds ≥7.5% (10-year) and ≥20% (30-year) · 10-14 years after delivery
- Results similar when assessed at thresholds of ≥7.5% at 10 years and ≥20% at 30 years
Original publication
Hypertensive disorders of pregnancy and gestational diabetes mellitus and predicted risk of maternal cardiovascular disease 10–14 years after delivery: A prospective cohort. Diabet Med. Published 17 January 2025. doi:10.
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