Highly Uncontrolled Cardiovascular Risk in Emerging Adults With Paediatric‐Onset Type 1 Diabetes—A Cross‐Sectional Analysis From the Diabetes Prospective Follow‐Up Registry DPV
Authors' conclusion
Young adults with paediatric-onset T1DM show a high burden of modifiable CVD risk factors with substantial treatment gaps, and clustering is associated with microvascular complications. Early identification and targeted intervention are critical to mitigating long-term vascular damage.
Study context
- Population
- Individuals aged 17–26 years with paediatric-onset T1D and ≥ 2 years diabetes duration, DPV registry, 2020–2023
- Participants
- 7,298 individuals
- Outcome
- Prevalence of five predefined CVD risk factors (HbA1c > 9%, obesity, elevated blood pressure, LDL > 130 mg/dL, smoking), using median values
- Follow-up
- 3-year observation period
Methodological detailsregistry-based (DPV), multivariable linear and logistic regression
- Registry-based (DPV)
- Multivariable linear and logistic regression
Main finding
As reported in the abstract
Prevalence of CVD risk factors
- ≥1 cardiovascular disease (CVD) risk factor
- 49.2%
- ≥2 risk factors
- 19.1%
- ≥3 risk factors
- 5.2%
- HbA1c > 9% (most frequent)
- 21.8%
- Elevated blood pressure (most frequent)
- 17.6%
Observational data: associations, not effects.
Further findings
Factors associated with CVD risk factor burden
- Burden associated with diabetes duration > 10 years and migration background
Microalbuminuria by number of CVD risk factors
- Likelihood increased progressively with number of risk factors; OR with four risk factors
- 2.68 (95% CI: 1.34-5.36)
Indication-treatment gaps
- Received medication, LDL cholesterol > 130 mg/dL
- 9.9%
- Received medication, hypertension > 140/90 mmHg
- 19.8%
Original publication
Highly Uncontrolled Cardiovascular Risk in Emerging Adults With Paediatric‐Onset Type 1 Diabetes—A Cross‐Sectional Analysis From the Diabetes Prospective Follow‐Up Registry DPV. Diabetes Obes Metab. Published 16 March 2026. doi:10.
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