Higher HbA1c variability is associated with increased arterial stiffness in individuals with type 1 diabetes
An erratum to this article was published (Cardiovasc Diabetol, 8 Apr 2023 ↗)
Authors' conclusion
An association independent of HbA1c-mean was found between HbA1c variability and arterial stiffness, suggesting a need to consider multiple HbA1c metrics in studies assessing cardiovascular risk in type 1 diabetes. Longitudinal and interventional studies are needed to confirm any causal relationship and to find strategies for reducing long-term glycaemic variability.
Study context
- Population
- Adults with T1D; HbA1c data from the preceding 10 years; mean age 47.1 (± 12.0) years, median diabetes duration 31.2 (21.2–41.3) years305 men · 368 women
- Participants
- 673 adults
- Outcome
- Association of HbA1c variability (adj-HbA1c-SD, HbA1c-CV, HbA1c-ARV) with arterial stiffness (cfPWV, AIx)
Methodological detailsMedian number of HbA1c assessments per individual 17 (12-26)
- Median number of HbA1c assessments per individual 17 (12-26)
Main finding
As reported in the abstract
HbA1c variability vs arterial stiffness
- All three HbA1c variability indices correlated with carotid-femoral pulse wave velocity (cfPWV) and augmentation index (AIx), adjusted for sex and age
- p < 0.001
- adj-HbA1c-SD associated with cfPWV, multivariable model incl. HbA1c-mean
- p = 0.032
- HbA1c-CV associated with cfPWV, multivariable model incl. HbA1c-mean
- p = 0.046
- adj-HbA1c-SD associated with AIx, multivariable model incl. HbA1c-mean
- p = 0.028
- HbA1c-CV associated with AIx, multivariable model incl. HbA1c-mean
- p = 0.049
Observational data: associations, not effects.
Original publication
Higher HbA1c variability is associated with increased arterial stiffness in individuals with type 1 diabetes. Cardiovasc Diabetol. Published 4 March 2023. doi:10.
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