Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload: Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the The Environmental Determinants of Diabetes in the Young (TEDDY) Study
Main finding · IA with insulin as first autoantibody, children with GRS ≥2 iron risk allelesResult — go to the resultAdjusted hazard ratio 1.71 95% CI 1.14–2.58Authors' conclusion
Iron intake may alter the risk of IA in children with high-risk HLA haplogenotypes.
Study context
- Population
- Genetically high-risk children followed from birth (TEDDY study)
- Participants
- 7,770 children
- Exposure
- High vs moderate energy-adjusted iron intake, by genetic risk score (GRS) for increased circulating iron
- Outcome
- Islet autoimmunity (IA) and progression to T1D
Methodological detailsbirth cohort, genetically high-risk children
- Birth cohort
- Genetically high-risk children
Main finding
As reported in the abstract
IA with insulin as first autoantibody, children with GRS ≥2 iron risk alleles
Adjusted hazard ratio
1.71
95% CI 1.14–2.58
High iron intakevs Moderate iron intake
aHR 1.71 (95% CI 1.14–2.58)
Observational data: associations, not effects.
Original publication
Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload: Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study. Diabetes Care. Published 3 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →