Gestational diabetes & diabetes in pregnancy
High fasting plasma glucose in early pregnancy and increased risk of adverse pregnancy outcomes in Chinese women: the role of gestational age
Main finding · CAPOResult — go to the resultAdjusted odds ratio 1.18 95 % CI 1.09–1.29Authors' conclusion
Early GDM could be defined as FPG 5.1-6.9 mmol/L at 9-19 gestational weeks among Chinese pregnant women.
Study context
- Population
- Pregnant women in Tianjin, China
- Participants
- 19,134 women
- Exposure
- Fasting plasma glucose (FPG) 5.1-6.9 mmol/L before 20 gestational weeks vs lower FPG
- Outcome
- Composite adverse pregnancy outcome (CAPO):
- Pregnancy-induced hypertension
- Macrosomia
- LGA
- Preterm birth
- Perinatal death
- Apgar score at 1 min < 7
Main finding
CAPO · FPG before 20 gestational weeks
Adjusted odds ratio
1.18
95 % CI 1.09–1.29
FPG 5.1-6.9 mmol/L before 20 gestational weeksvs lower FPG
aOR 1.18 (95 % CI 1.09–1.29)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Macrosomia · FPG before 20 gestational weeks
| aOR (95 % CI) | ||
|---|---|---|
| FPG 5.1-6.9 mmol/L | 1.28 (1.15–1.44) | |
| 0.512Adjusted odds ratio (log scale) |
Large for gestational age (LGA) · FPG before 20 gestational weeks
| aOR (95 % CI) | ||
|---|---|---|
| FPG 5.1-6.9 mmol/L | 1.27 (1.15–1.41) | |
| 0.512Adjusted odds ratio (log scale) |
Composite adverse pregnancy outcome (CAPO), macrosomia and LGA after excluding women with gestational diabetes mellitus (GDM) at 24-28 weeks
- Risk associations persisted
CAPO, macrosomia and LGA by gestational age at FPG measurement
- FPG 5.1-6.9 mmol/L at 9-19 weeks but not before 9 weeks associated with increased risk, with significant additive interactions
Original publication
High fasting plasma glucose in early pregnancy and increased risk of adverse pregnancy outcomes in Chinese women: the role of gestational age. Diabetes Res Clin Pract. Published 25 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →