Gestational diabetes & diabetes in pregnancy
Impact of Automated Insulin Delivery on Glycemic Profile and Maternal/Neonatal Outcomes in Pregnancy: A Review of the Evidence From Observational Studies
Authors' conclusion
The real-world evidence generated by these observational studies provides invaluable information for patients and providers seeking to improve outcomes for gravidas with T1D.
Study context
- Population
- Pregnancies in gravidas with T1D managed antenatally with automated insulin delivery (AID) (off-label use)24 publications
- Participants
- 243 pregnancies
- Exposure
- Antenatal AID vs other methods of insulin delivery; open-source vs commercial AID
- Open-source AIDn = 16
- Outcome
- Glycemic, maternal and neonatal outcomes with antenatal AID
Main finding
As reported in the abstract
- Largely reassuring outcomes data
- Time in range (TIR) with commercial AID generally acceptable; many reached pregnancy target TIR > 70% by third trimester
- TIR with open-source AID appeared higher, with potential tradeoff of worse time below range (TBR)
- No apparent major differences in pregnancy outcomes between AID and other insulin delivery methods (largely indirect comparisons)
- Clinical outcomes appear superior with open-source vs commercial AID; interpret with caution (small sample, potential confounding)
Observational data: associations, not effects.
Original publication
Impact of Automated Insulin Delivery on Glycemic Profile and Maternal/Neonatal Outcomes in Pregnancy: A Review of the Evidence From Observational Studies. J Diabetes Sci Technol. Published 22 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →