Hemoglobin Glycation Index: A Novel Risk Factor for Incident Chronic Kidney Disease in an Apparently Healthy Population
An erratum to this article was published (J Clin Endocrinol Metab, 17 May 2024 ↗)
Authors' conclusion
HGI was a novel risk factor for CKD in the general population.
Study context
- Population
- Chronic kidney disease (CKD)-free health examinees, general population (4.1% with diabetes)2,540 developed CKD
- Participants
- 23,467 examinees
- Exposure
- Hemoglobin glycation index (HGI) as a predictor of incident CKD
- Outcome
- Incident CKD (dipstick proteinuria or eGFR < 60 mL/min/1.73 m²)
- Follow-up
- Mean 5.1 years
Methodological detailsCox proportional hazards model with multivariate adjustment, propensity score matching (second group)
- Cox proportional hazards model with multivariate adjustment
- Propensity score matching (second group)
Main finding
As reported in the abstract
Incident CKD · mean 5.1 years
HR of HGI for CKD, adjusted for 11 covariates
1.293
95% CI 1.238 to 1.349P < .0001
Population attributable risk of HGI for CKD
4.2%
Observational data: associations, not effects.
Further findings
HGI level in subjects with CKD, propensity-score matched group (N = 2580; 708 matched 1:1 for 9 covariates)
- HGI significantly elevated in subjects with CKD
- P = 0.03
- Propensity score matching
Original publication
Hemoglobin Glycation Index: A Novel Risk Factor for Incident Chronic Kidney Disease in an Apparently Healthy Population. J Clin Endocrinol Metab. Published 1 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →