Health-Related Quality of Life and Thyroid Cancer-Specific Symptoms in Patients Treated for Differentiated Thyroid Cancer: A Single-Center Cross-Sectional Survey from Mainland China
Authors' conclusion
Thyroid cancer patients experience multiple health-related problems and disease-specific symptoms after completing primary treatment. Patients with a duration ≤6 months from the completion of primary treatment, those with a history of lateral neck dissection, and a current TSH level ≤0.5 mIU/L may be more likely to have impaired generic QOL. More thyroid cancer-specific symptoms may be associated with higher cumulative activities of RAI, gender (women), postoperative hypoparathyroidism, a history of lateral neck dissection, lower monthly household income, and conventional surgery.
Study context
- Population
- DTC survivors after primary treatment, Mainland China
- Participants
- 373 survivors
- Outcome
- Generic and disease-specific health-related quality of life (HR-QOL) (EORTC QLQ-C30, THYCA-QOL) and associated factors
Methodological detailssingle-centre, survey
- Single-centre
- Survey
Main finding
As reported in the abstract
QLQ-C30 global score, mean (SD)
73.12
11.95
THYCA-QOL summary score, mean (SD)
34.50
12.68
Observational data: associations, not effects.
Further findings
Factors associated with worse global quality-of-life (QOL) (QLQ-C30)
- Shorter time since completing primary treatment (≤6 months), lateral neck dissection, lower current TSH (≤0.5 mIU/L)
Factors associated with thyroid cancer-specific QOL (THYCA-QOL)
- Worse: cumulative radioiodine (RAI) >100 mCi, women, postoperative hypoparathyroidism, lateral neck dissection
- Better: monthly household income >5000￥, minimally invasive thyroid surgery
Original publication
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