A Comparison of Outcomes in Medullary Thyroid Carcinoma Patients With and Without a Preoperative Diagnosis: A Multicenter Retrospective Cohort Study
Authors' conclusion
Preoperatively, the diagnosis of MTC is often missed.
Study context
- Population
- Patients with histologically confirmed medullary thyroid carcinoma (MTC) treated in Israel, January 2000 to June 2021; mean age 56.2 ± 14.3 years, 43% males
- Participants
- 94 patients
- Exposure
- Preoperative MTC diagnosis vs no preoperative diagnosis
- preop-Dxn = 53
- no-Dxn = 41reference
- Outcome
- Biochemical cure
- Follow-up
- Last
Methodological detailsmulticenter
- Multicenter
Main finding
As reported in the abstract
P = 0.41
Observational data: associations, not effects.
Further findings
Total thyroidectomy · including completion procedures
P = 0.002
Central LND
P < 0.001
Ipsilateral lateral LND
P < 0.001
Contralateral lateral LND
NS
Micro-MTC (size ≤10 mm)
P = 0.03
Co-occurring follicular cell-derived carcinoma
P = 0.003
Tumor size
P = 0.09
| Outcome | preop-Dx | no-Dx | P value |
|---|---|---|---|
| Biochemical cure, excluding micro-MTC | 62% (CI 0.46–0.77) | 33% (CI 0.14–0.52) | P = 0.04 |
- Overall survival · median follow-up 82 months (IQR 30-153) · improved OS with preop-Dx
- log-rank p = 0.04
Extrathyroidal and extranodal tumor extension
- Not significantly different between the groups
Original publication
A Comparison of Outcomes in Medullary Thyroid Carcinoma Patients With and Without a Preoperative Diagnosis: A Multicenter Retrospective Cohort Study. Thyroid. Published 15 March 2023. doi:10.
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