Persistent or Recurrent Disease in Thyroid Cancer Survivors Who Have Elevated Serum Antithyroglobulin Antibodies
Authors' conclusion
We conclude that individuals with elevated serum TgAb at the outset should be followed with a higher index of suspicion for persistent/recurrent thyroid cancer.
Study context
- Population
- Differentiated thyroid cancer survivors seen at one major academic medical center
- Participants
- 277 participants
- Exposure
- Elevated vs low or normal perioperative serum antithyroglobulin antibody
- Outcome
- Persistent or recurrent thyroid cancer
- Follow-up
- Median 7.54 years
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Persistent/recurrent disease
- Significantly higher incidence of persistent/recurrent disease in TgAb+ vs TgAb (TgAb-), significant in univariable and multivariable (TgAb status, age, sex) Cox proportional hazards analysis
Observational data: associations, not effects.
Further findings
Positive lymph nodes at initial surgery and AJCC stage
- TgAb+ more likely to have positive lymph nodes at initial surgery and a higher American Joint Committee on Cancer stage
Original publication
Persistent or Recurrent Disease in Thyroid Cancer Survivors Who Have Elevated Serum Antithyroglobulin Antibodies. Endocr Pract. Published 6 March 2023. doi:10.
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