The Diagnostic Value of 18 F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Differentiated Thyroid Cancer Patients with Elevated Thyroglobulin/Thyroglobulin Antibody Levels and Negative Iodine Scintigraphy: A Systematic Review and Meta-Analysis
An erratum to this article was published (Thyroid, Jan 2024 ↗)
Authors' conclusion
There is moderate quality evidence demonstrating the high diagnostic accuracy of FDG PET/CT in detecting recurrence in patients with DTC with negative WBS and elevated serum Tg or TgAb levels.
Study context
- Population
- Patients with differentiated thyroid cancer (DTC) with negative whole-body scans and elevated serum thyroglobulin (Tg) or thyroglobulin antibody (TgAb) levels; articles published January 2012–June 2023 (MEDLINE, EMBASE, Cochrane)
- Participants
- 1,988 patients24 studies
- Outcome
- Diagnostic accuracy of FDG PET/CT for detection of recurrence
Methodological detailsPRISMA-DTA, Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) framework, subgroup analyses by Tg/TgAb and TSH stimulation status
- PRISMA-DTA
- GRADE framework
- Subgroup analyses by Tg/TgAb and TSH stimulation status
Pooled result
As reported in the abstract
Pooled diagnostic accuracy of FDG PET/CT for recurrence (overall)
Pooled sensitivity
0.87
95% CI 0.83–0.92; I2 = 75%
Pooled specificity
0.84
CI 0.80–0.89; I2 = 44%
Further pooled results
| Outcome | Values |
|---|---|
| Treatment plan changed after FDG PET/CT | FDG PET/CT 40% (CI 34–47%) |
- Treatment plan changed after FDG PET/CT: I2 = 39%
Diagnostic accuracy by subgroup (serum Tg or TgAb levels, TSH stimulation status)
- No significant differences in diagnostic accuracy of FDG PET/CT across subgroups by serum Tg or TgAb levels and TSH stimulation status
Original publication
The Diagnostic Value of 18 F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Differentiated Thyroid Cancer Patients with Elevated Thyroglobulin/Thyroglobulin Antibody Levels and Negative Iodine Scintigraphy: A Systematic Review and Meta-Analysis. Thyroid. Published 19 September 2023. doi:10.
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