Gestational diabetes & diabetes in pregnancy

Habitual carbohydrate intake is not correlated with circulating β-hydroxybutyrate levels in pregnant women with overweight and obesity at 28 weeks' gestation

DiabetologiaPublished Secondary analysis of the SPRING randomised controlled trial

Authors' conclusion

Fasting serum β-hydroxybutyrate levels are not associated with habitual carbohydrate intake at 28 weeks' gestation in pregnant women with overweight and obesity.

Study context

Population
Pregnant women with overweight or obesity at 28 weeks' gestation; mean BMI 34.7 ± 6.3 kg/m²
Participants
108 women
Comparison
High vs low habitual carbohydrate intake
Primary endpoint
Association of fasting maternal ketone (β-hydroxybutyrate) levels with habitual carbohydrate intake
Follow-up
28 weeks' gestation

Primary result

As reported in the abstract

Fasting β-hydroxybutyrate

Further findings

Fasting β-hydroxybutyrate range

Range
22.2 to 296.5 μmol/l

Habitual carbohydrate intake

Median (IQR)
155 [126-189] g/day

Correlation of fasting β-hydroxybutyrate with 1 h venous plasma glucose during 75 g OGTT

ρ
0.23, p=0.03
Only metabolic parameter correlated with fasting β-hydroxybutyrate

Original publication

Habitual carbohydrate intake is not correlated with circulating β-hydroxybutyrate levels in pregnant women with overweight and obesity at 28 weeks' gestation. Diabetologia. Published 16 November 2023. doi:10.1007/s00125-023-06044-w

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