Gestational diabetes & diabetes in pregnancy
MiniMed TM 780G Advanced Hybrid Closed-Loop System Study in Pregnant Women with Type 1 Diabetes
Authors' conclusion
The AHCL system provided good glucose control during pregnancy and recommendation targets were reached during the nocturnal period only. The maternal and neonatal complications remained high.
Study context
- Population
- Pregnant women with T1D treated with the advanced hybrid closed-loop (AHCL) system, April 2021 to September 2022; age 33 ± 3 years, HbA1c 7.3% ± 0.7%, 1 twin pregnancyincl
- Participants
- 13 women
- Outcome
- TIR (63-140 mg/dL)
- Follow-up
- First 2 weeks of pregnancy to first, second and third trimester
Methodological detailsmulticentre, single-group
- Multicentre
- Single-group
Main finding
As reported in the abstract
- Time in range (TIR) during first 2 weeks of pregnancy
- 46% (34-55)
- TIR first trimester
- 54% (51-59) (P < 0.01)
- TIR second trimester
- 64% (48-68) (P < 0.01)
- TIR third trimester
- 66% (60-70) (P < 0.001)
- Nocturnal TIR (63-140 mg/dL) throughout pregnancy
- >70%
Observational data: associations, not effects.
Further findings
Time below range <63 mg/dL
- Early pregnancy
- 0.5% (0-2)
- First trimester
- 1.3% (0.7-2.2)
- Second trimester
- 2% (1.2-3.5) (P < 0.05)
- Third trimester
- 1.3% (1.31-3) (P < 0.05)
Insulin dose and HbA1c at delivery
- Insulin dose increased to
- 0.89 ± 0.35 IU/kg/day (P < 0.01)
- HbA1c decreased to
- 6.4% ± 0.6% (P = 0.005)
Reported carbohydrate amount · early pregnancy to delivery
- Increased from 167 ± 363 g/d to
- 243 ± 106 g/d (P < 0.01)
Gestational age and birthweight · delivery
- Gestational age
- 37 ± 2 weeks
- Birthweight
- 3134 ± 711 g
Safety
Maternal-neonatal complications
- Macrosomia
- 5/14
- Neonatal hypoglycemia
- 2/14
- Preeclampsia
- 5/13
- Cesarean section (incl. 3 scarred uterus)
- 9/13
Original publication
MiniMed TM 780G Advanced Hybrid Closed-Loop System Study in Pregnant Women with Type 1 Diabetes. Diabetes Technol Ther. Published 14 November 2023. doi:10.
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