Glycemic status, early-onset and late-onset dementia, dementia-free lifespan, and brain structure: A population-based cohort study
Authors' conclusion
Better glycemic status was associated with reduced EOD and LOD risks, prolonged dementia-free lifespan, and brain MRI measures, partiality mediated by depressive episode. These findings support the potential significance of reaching ideal glycemic status to prevent dementia onset and prolong dementia-free longevity at the early pre-symptomatic stage in young diabetes.
Study context
- Population
- UK Biobank participants; Early-onset dementia (EOD) cohort mean (SD) age 51.5 (5.9) years, late-onset dementia (LOD) cohort mean (SD) age 60.7 (5.0) years286,743 (EOD), 330,103 (LOD)
- Exposure
- Optimal glycemic control vs worse glycemic status in DM
- Outcome
- Incident EOD (dementia diagnosis before age 65) and LOD (dementia after age 65)
Main finding
As reported in the abstract
EOD incidence lower with optimal glycemic control vs worse glycemic status
47 %
LOD incidence lower with optimal glycemic control vs worse glycemic status
17 %
Observational data: associations, not effects.
Further findings
Dementia-free lifespan at age 50
- Longer dementia-free lifespan with optimal glycemic control, up to
- 3.2 years
Brain MRI structure
- Better dementia-related brain structure measures with optimal glycemic control
Mediation by incident depressive episode
%
- Proportion mediated, EOD (P = 0.014)
- 18.8
- Proportion mediated, LOD (P < 0.001)
- 7.8
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →