Optimizing cardiovascular health with a type 2 diabetes remission program: Ultraprocessed food‐intake reduction, Mediterranean diet, chrononutrition and physical training—The DIABEPIC ‐2 pilot study
Authors' conclusion
The DIABEPIC-2 program enabled a significant proportion of participants to achieve T2D remission and to improve their cardiovascular health; therefore, it would be relevant to confirm these results. The recruitment and visit completion rates observed in this pilot study further demonstrate its feasibility, supporting the rationale for conducting a larger randomized clinical trial.
Study context
- Population
- Adults with T2D; mean age 63.6 ± 9.2 years, initial mean HbA1c 6.7 ± 0.7%, mean T2D duration 7.4 ± 6.7 years34 completed
- Comparison
- 6-month programme, with or without intermittent fasting (IF) add-on
- Outcome
- Feasibility of the programme
- Follow-up
- 6 months
Methodological detailssingle-arm programme, randomised 2:1 intermittent fasting add-on in last 3 months
- Single-arm programme
- Randomised 2:1 intermittent fasting add-on in last 3 months
Main finding
As reported in the abstract
Feasibility
Recruitment rate
6.4 participants/month
Completed the programme
34 participants
81%
Attendance rate
87%
Further findings
Weight change · 6 months
- Mean weight loss (all participants)
- −6.8 kg (−9.3 to −4.4, p < 0.001)
Cardiometabolic health, anthropometric parameters, cardiorespiratory fitness and food matrix quality
- Overall, participants significantly improved cardiometabolic health and anthropometric parameters, cardiorespiratory fitness, and food matrix quality
IF add-on
- Participants randomised to the IF add-on did not show significant additional improvement
Original publication
Optimizing cardiovascular health with a type 2 diabetes remission program: Ultraprocessed food‐intake reduction, Mediterranean diet, chrononutrition and physical training—The DIABEPIC ‐2 pilot study. Diabetes Obes Metab. Published 18 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →