Early findings from the National Health Service (NHS) Type 2 Diabetes Path to Remission Programme: a prospective evaluation of real-world implementation
Authors' conclusion
Findings from the NHS T2DR programme show that remission of type 2 diabetes is possible outside of research settings, through at-scale service delivery. However, the rate of remission achieved is lower and the ascertainment of data is more limited with implementation in the real world than in randomised controlled trial settings.
Study context
- Population
- People in England aged 18–65 years diagnosed with T2D in the last 6 years, referred to the NHS T2DR programme (12-month behavioural intervention with initial 3-month total diet replacement (TDR)) between Sept 1, 2020, and Dec 31, 2022referred
- Participants
- 7,540 people
- Exposure
- Started TDR before January, 2022 vs Completed programme
- Started TDR before January, 2022n = 1,710
- Completed programmen = 945
- Outcome
- Remission of T2D: two HbA1c <48 mmol/mol at least 3 months apart, no glucose-lowering medications from 3 months before the first, second HbA1c 11-15 months after programme start
- Follow-up
- 1 year
Methodological detailsnational, real-world implementation
- National
- Real-world implementation
Main finding
As reported in the abstract
Remission of T2D
Observational data: associations, not effects.
Further findings
| Outcome | Started TDR before January, 2022 | Completed programme |
|---|---|---|
| Weight lossMean | 8.3% (CI 7.9–8.6) | 9.3% (CI 8.8–9.8) |
| kg | 9.4 kg (8.9-9.8) | 10.3 kg (9.7-10.9) |
| Weight loss among those with remissionMean | 13.4% (CI 12.3–14.5) | 14.4% (CI 13.2–15.5) |
| kg | 14.8 kg (13.4-16.3) | 15.9 kg (14.3-17.4) |
- Weight loss: 95% CI
Programme completion · 12 months
- Completed the programme (weight recorded at 12 months), of those starting TDR before January, 2022
- 960 (55%)
Original publication
Early findings from the NHS Type 2 Diabetes Path to Remission Programme: a prospective evaluation of real-world implementation. Lancet Diabetes Endocrinol. Published 5 August 2024. doi:10.
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