Glucose variability measured by continuous glucose monitoring is associated with skin autofluorescence: the Maastricht Study
Authors' conclusion
A higher glucose variability is associated with higher levels of SAF, suggesting that glucose variability plays a role in the formation of AGEs.
Study context
- Population
- People with and without impaired fasting glucose, impaired glucose tolerance or diabetes, Maastricht Study; mean ± SD age 59 ± 8.7 years; 49% female
- Participants
- 795 people
- Exposure
- Glucose variability vs skin autofluorescence
- Normal glucose metabolismn = 459
- Prediabetesn = 174
- T2Dn = 162
- Outcome
- Association of CGM-metrics CV and SD with SAF (AGEs in skin)
Methodological detailsthe Maastricht Study, multiple linear regression, fully adjusted
- The Maastricht Study
- Multiple linear regression
- Fully adjusted
Main finding
As reported in the abstract
Association of glucose variability with SAF, fully adjusted
SD significantly associated with skin autofluorescence (SAF) (IQR 0.088-0.217)
0.152 AU
CV significantly associated with SAF (IQR 0.005-0.017)
0.014 AU
Observational data: associations, not effects.
Further findings
SAF by glucose metabolism status — T2D vs Prediabetes · higher SAF with T2D
P = 0.014
| Outcome | P value |
|---|---|
| SAF by glucose metabolism statusT2D vs Normal glucose metabolism · higher SAF with T2D | P = 0.007 |
Effect modification by glucose metabolism status
- Glucose metabolism status did not modify the associations of SD and CV with SAF
Original publication
Glucose variability measured by continuous glucose monitoring is associated with skin autofluorescence: the Maastricht Study. Diabetologia. Published 20 June 2025. doi:10.
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