Inverse association between glucose variability and body fat in type 2 diabetes with impaired endogenous insulin secretion assessed using continuous glucose monitoring: A prospective observational study
Authors' conclusion
The contribution of body fat mass to GV depends on the endogenous insulin secretion residue. A small body fat area has independent adverse effects on GV in people with type 2 diabetes and impaired endogenous insulin secretion.
Study context
- Population
- People with T2D who underwent ambulatory CGM, abdominal CT and fasting blood sampling
- Participants
- 193 people
- Exposure
- High fasting C-peptide (FCP) vs low FCP subgroups
- Outcome
- Contribution of body fat mass and serum adiponectin to glucose variability (CV)
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
CV in glucose variability (GV) vs abdominal fat area (multivariate regression)
Low FCP: high coefficient of variation (CV) related to small abdominal visceral fat area
β = −0.11, SE 0.03
P < 0.05
Low FCP: high CV related to small subcutaneous fat area
β = −0.09, SE 0.04
P < 0.05
Observational data: associations, not effects.
Further findings
Serum adiponectin and CGM-related variables
- No significant relationship
Original publication
Inverse association between glucose variability and body fat in type 2 diabetes with impaired endogenous insulin secretion assessed using continuous glucose monitoring: A prospective observational study. Diabetes Obes Metab. Published 31 March 2023. doi:10.
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