Diabetic peripheral neuropathy and glycemic variability assessed by continuous glucose monitoring: A systematic review and meta-analysis
Authors' conclusion
Our findings support a link between higher GV and an increased risk of DPN in patients with diabetes.
Study context
- Population
- Patients with T1D and T2D with continuous glucose monitoring (CGM)-derived glycemic variability (GV) metrics
- Participants
- 3,649 patients9 studies
- Comparison
- Higher vs lower CGM-derived glycemic variability
- Outcome
- Association between GV metrics and risk of developing diabetic peripheral neuropathy (DPN)
Pooled result
As reported in the abstract
Incidence of DPN by increased GV metric
SD: OR
2.58 (1.45-4.57) (95% CI)
Mean amplitude of glycemic excursions (MAGE): OR
1.90 (1.01-3.58) (95% CI)
Mean of daily difference (MODD): OR
2.88 (2.17-3.81) (95% CI)
Original publication
Diabetic peripheral neuropathy and glycemic variability assessed by continuous glucose monitoring: A systematic review and meta-analysis. Diabetes Res Clin Pract. Published 27 June 2024. doi:10.
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