Adaptive selection at G6PD and disparities in diabetes complications
Authors' conclusion
Across continentally defined ancestral populations, the differences in frequency of rs1050828 -T and other G6PDdef alleles contribute to disparities in diabetes complications.
Study context
- Population
- Individuals with diabetes; Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial and Million Veteran Program participants
- Comparison
- G6PDdef vs no G6PDdef
- Outcome
- Diabetic retinopathy
Methodological detailscombined-ancestry
- Combined-ancestry
Main finding
As reported in the abstract
Diabetic retinopathy GWAS
- Loci identified, incl. G6PDdef causal variant rs1050828 -T (Val98Met)
- 9
Further findings
Glucose and hemoglobin A1c (HbA1c) before diabetes diagnosis and insulin prescription
- Glucose significantly higher and HbA1c significantly lower with vs without G6PDdef
Incident retinopathy and neuropathy (ACCORD)
- Significantly higher hazards with G6PDdef
Retinopathy at the same HbA1c levels (ACCORD and Million Veteran Program)
- Significantly increased risk with G6PDdef
Attributable fraction in participants of African ancestry
- Diabetic retinopathy cases due to G6PDdef
- 12%
- Diabetic neuropathy cases due to G6PDdef
- 9%
- Estimate
Original publication
Adaptive selection at G6PD and disparities in diabetes complications. Nat Med. Published 25 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →