Glucose levels measured with continuous glucose monitoring in uncomplicated pregnancies
Authors' conclusion
Mean glucose levels and time 63-120 mg/dL (3.5-6.7 mmol/L) remained nearly stable throughout pregnancy and values above 140 mg/dL (7.8 mmol/L) were rare. Mean glucose levels in pregnancy trend higher as BMI increases into the overweight/obesity range. The glycemic metrics reported during uncomplicated pregnancies represent treatment targets for pregnant individuals.
Study context
- Population
- Pregnant individuals aged ≥18 years enrolled before 17 gestational weeks with uncomplicated pregnancy (HbA1c <5.7% in early pregnancy; no large-for-gestational-age birth, hypertensive disorders of pregnancy or GDM), wearing Dexcom G6 continuous glucose monitoring (CGM); mean±SD body mass index (BMI) 25.3±5.0 kg/m²of 937 enrolled
- Participants
- 413 individuals
- Outcome
- CGM-measured glycemic metrics during gestation
- Follow-up
- Throughout gestation
Methodological detailstwo sites, Mealtimes voluntarily recorded
- Two sites
- Mealtimes voluntarily recorded
Main finding
As reported in the abstract
CGM glycemic metrics during gestation
- Overall mean±SD glucose
- 98±7 mg/dL (5.4±0.4 mmol/L)
- Median % time 63-120 mg/dL (3.5-6.7 mmol/L)
- 86% (IQR: 82-89%)
- Median % time <63 mg/dL (3.5 mmol/L)
- 1.8%
- Median % time >120 mg/dL (6.7 mmol/L)
- 11%
- Median % time >140 mg/dL (7.8 mmol/L)
- 2.5%
- Mean post-prandial peak glucose
- 126±22 mg/dL (7.0±1.2 mmol/L)
- Mean post-prandial glycemic excursion
- 36±22 mg/dL (2.0±1.2 mmol/L)
Observational data: associations, not effects.
Further findings
Mean glucose by BMI
- Mean glucose by BMI — Correlation of higher mean glucose with higher BMI (low to moderate)
- r=0.35
Original publication
Glucose levels measured with continuous glucose monitoring in uncomplicated pregnancies. BMJ Open Diabetes Res Care. Published 10 May 2024. doi:10.
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